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human kidney cancer cell lines caki1  (ATCC)


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    ATCC human kidney cancer cell lines caki1
    MYPT1 suppressed ccRCC metastasis in vivo . (A) The lung metastasis model showed that MYPT1 overexpression significantly inhibited ccRCC lung metastasis. Representative gross images of the lungs and bioluminescence images of lung metastases are shown. Arrows indicate pulmonary metastatic nodules. Scale bars: 500 μm. (B, C) Nude mice injected with MYPT1‐overexpressing <t>Caki1</t> cells had fewer and smaller lung metastases. Representative images of HE staining of the lungs and statistical analysis results are shown. Scale bars: 200 or 50 μm. The pulmonary metastatic nodules were counted under a microscope, and the results were summarized. Data presented as mean ± SEM ( n = 5). Statistical analysis was performed with a two‐tailed unpaired Student's t test (* P < 0.05). ccRCC, renal clear cell carcinoma; HE, haematoxylin–eosin; MYPT1, myosin phosphatase target subunit 1.
    Human Kidney Cancer Cell Lines Caki1, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 299 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+kidney+cancer+cell+lines+caki1/Caki-1/pmc09623519-33-1-13
    Average 96 stars, based on 299 article reviews
    human kidney cancer cell lines caki1 - by Bioz Stars, 2026-09
    96/100 stars

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    1) Product Images from "MYPT1 inhibits the metastasis of renal clear cell carcinoma via the MAPK8 /N‐cadherin pathway"

    Article Title: MYPT1 inhibits the metastasis of renal clear cell carcinoma via the MAPK8 /N‐cadherin pathway

    Journal: FEBS Open Bio

    doi: 10.1002/2211-5463.13487

    MYPT1 suppressed ccRCC metastasis in vivo . (A) The lung metastasis model showed that MYPT1 overexpression significantly inhibited ccRCC lung metastasis. Representative gross images of the lungs and bioluminescence images of lung metastases are shown. Arrows indicate pulmonary metastatic nodules. Scale bars: 500 μm. (B, C) Nude mice injected with MYPT1‐overexpressing Caki1 cells had fewer and smaller lung metastases. Representative images of HE staining of the lungs and statistical analysis results are shown. Scale bars: 200 or 50 μm. The pulmonary metastatic nodules were counted under a microscope, and the results were summarized. Data presented as mean ± SEM ( n = 5). Statistical analysis was performed with a two‐tailed unpaired Student's t test (* P < 0.05). ccRCC, renal clear cell carcinoma; HE, haematoxylin–eosin; MYPT1, myosin phosphatase target subunit 1.
    Figure Legend Snippet: MYPT1 suppressed ccRCC metastasis in vivo . (A) The lung metastasis model showed that MYPT1 overexpression significantly inhibited ccRCC lung metastasis. Representative gross images of the lungs and bioluminescence images of lung metastases are shown. Arrows indicate pulmonary metastatic nodules. Scale bars: 500 μm. (B, C) Nude mice injected with MYPT1‐overexpressing Caki1 cells had fewer and smaller lung metastases. Representative images of HE staining of the lungs and statistical analysis results are shown. Scale bars: 200 or 50 μm. The pulmonary metastatic nodules were counted under a microscope, and the results were summarized. Data presented as mean ± SEM ( n = 5). Statistical analysis was performed with a two‐tailed unpaired Student's t test (* P < 0.05). ccRCC, renal clear cell carcinoma; HE, haematoxylin–eosin; MYPT1, myosin phosphatase target subunit 1.

    Techniques Used: In Vivo, Over Expression, Injection, Staining, Microscopy, Two Tailed Test

    RNA sequencing and bioinformatic analyses demonstrated that MYPT1 is involved in a MAPK‐related pathway in ccRCC. (A) The volcano plot shows genes differentially expressed between Caki1 cells with MYPT1 overexpression group and the negative control group ( P < 0.05). (B) KEGG analysis of the differentially expressed genes (¦log2FC¦ > 1, FDR‐adjusted P < 0.05) was performed in Caki1‐NC and Caki1‐MYPT1 cells. (C) GSEA revealed that the MAPK signalling pathway gene set was less enriched in Caki1‐MYPT1 cells (FDR < 25% and P < 0.05). (D) KEGG analysis of the MYPT1‐correlated genes ( P < 0.05) in the TCGA‐KIRC dataset. (E) The 17 overlapping genes were enriched in the MAPK pathway based on the differentially expressed genes from RNA sequencing data or MYPT1‐correlated genes from TCGA‐KIRC dataset. ccRCC, renal clear cell carcinoma; GSEA, Gene Set Enrichment Analysis; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen‐activated protein kinase; MYPT1, myosin phosphatase target subunit 1.
    Figure Legend Snippet: RNA sequencing and bioinformatic analyses demonstrated that MYPT1 is involved in a MAPK‐related pathway in ccRCC. (A) The volcano plot shows genes differentially expressed between Caki1 cells with MYPT1 overexpression group and the negative control group ( P < 0.05). (B) KEGG analysis of the differentially expressed genes (¦log2FC¦ > 1, FDR‐adjusted P < 0.05) was performed in Caki1‐NC and Caki1‐MYPT1 cells. (C) GSEA revealed that the MAPK signalling pathway gene set was less enriched in Caki1‐MYPT1 cells (FDR < 25% and P < 0.05). (D) KEGG analysis of the MYPT1‐correlated genes ( P < 0.05) in the TCGA‐KIRC dataset. (E) The 17 overlapping genes were enriched in the MAPK pathway based on the differentially expressed genes from RNA sequencing data or MYPT1‐correlated genes from TCGA‐KIRC dataset. ccRCC, renal clear cell carcinoma; GSEA, Gene Set Enrichment Analysis; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen‐activated protein kinase; MYPT1, myosin phosphatase target subunit 1.

    Techniques Used: RNA Sequencing, Over Expression, Negative Control

    Related Articles

    Cell Culture:

    Article Title: MYPT1 inhibits the metastasis of renal clear cell carcinoma via the MAPK8 /N‐cadherin pathway
    Article Snippet: .. The human kidney cancer cell lines Caki1 and 769P were commercially provided by American Type Culture Collection (ATCC) and cultured as per ATCC's guidelines. ..



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    human kidney cancer cell lines caki1  (ATCC)
    96
    ATCC human kidney cancer cell lines caki1
    MYPT1 suppressed ccRCC metastasis in vivo . (A) The lung metastasis model showed that MYPT1 overexpression significantly inhibited ccRCC lung metastasis. Representative gross images of the lungs and bioluminescence images of lung metastases are shown. Arrows indicate pulmonary metastatic nodules. Scale bars: 500 μm. (B, C) Nude mice injected with MYPT1‐overexpressing <t>Caki1</t> cells had fewer and smaller lung metastases. Representative images of HE staining of the lungs and statistical analysis results are shown. Scale bars: 200 or 50 μm. The pulmonary metastatic nodules were counted under a microscope, and the results were summarized. Data presented as mean ± SEM ( n = 5). Statistical analysis was performed with a two‐tailed unpaired Student's t test (* P < 0.05). ccRCC, renal clear cell carcinoma; HE, haematoxylin–eosin; MYPT1, myosin phosphatase target subunit 1.
    Human Kidney Cancer Cell Lines Caki1, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+kidney+cancer+cell+lines+caki1/Caki-1/pmc09623519-33-1-13
    Average 96 stars, based on 1 article reviews
    human kidney cancer cell lines caki1 - by Bioz Stars, 2026-09
    96/100 stars
    		  Buy from Supplier

    Image Search Results


    MYPT1 suppressed ccRCC metastasis in vivo . (A) The lung metastasis model showed that MYPT1 overexpression significantly inhibited ccRCC lung metastasis. Representative gross images of the lungs and bioluminescence images of lung metastases are shown. Arrows indicate pulmonary metastatic nodules. Scale bars: 500 μm. (B, C) Nude mice injected with MYPT1‐overexpressing Caki1 cells had fewer and smaller lung metastases. Representative images of HE staining of the lungs and statistical analysis results are shown. Scale bars: 200 or 50 μm. The pulmonary metastatic nodules were counted under a microscope, and the results were summarized. Data presented as mean ± SEM ( n = 5). Statistical analysis was performed with a two‐tailed unpaired Student's t test (* P < 0.05). ccRCC, renal clear cell carcinoma; HE, haematoxylin–eosin; MYPT1, myosin phosphatase target subunit 1.

    Journal: FEBS Open Bio

    Article Title: MYPT1 inhibits the metastasis of renal clear cell carcinoma via the MAPK8 /N‐cadherin pathway

    doi: 10.1002/2211-5463.13487

    Figure Lengend Snippet: MYPT1 suppressed ccRCC metastasis in vivo . (A) The lung metastasis model showed that MYPT1 overexpression significantly inhibited ccRCC lung metastasis. Representative gross images of the lungs and bioluminescence images of lung metastases are shown. Arrows indicate pulmonary metastatic nodules. Scale bars: 500 μm. (B, C) Nude mice injected with MYPT1‐overexpressing Caki1 cells had fewer and smaller lung metastases. Representative images of HE staining of the lungs and statistical analysis results are shown. Scale bars: 200 or 50 μm. The pulmonary metastatic nodules were counted under a microscope, and the results were summarized. Data presented as mean ± SEM ( n = 5). Statistical analysis was performed with a two‐tailed unpaired Student's t test (* P < 0.05). ccRCC, renal clear cell carcinoma; HE, haematoxylin–eosin; MYPT1, myosin phosphatase target subunit 1.

    Article Snippet: The human kidney cancer cell lines Caki1 and 769P were commercially provided by American Type Culture Collection (ATCC) and cultured as per ATCC's guidelines.

    Techniques: In Vivo, Over Expression, Injection, Staining, Microscopy, Two Tailed Test

    RNA sequencing and bioinformatic analyses demonstrated that MYPT1 is involved in a MAPK‐related pathway in ccRCC. (A) The volcano plot shows genes differentially expressed between Caki1 cells with MYPT1 overexpression group and the negative control group ( P < 0.05). (B) KEGG analysis of the differentially expressed genes (¦log2FC¦ > 1, FDR‐adjusted P < 0.05) was performed in Caki1‐NC and Caki1‐MYPT1 cells. (C) GSEA revealed that the MAPK signalling pathway gene set was less enriched in Caki1‐MYPT1 cells (FDR < 25% and P < 0.05). (D) KEGG analysis of the MYPT1‐correlated genes ( P < 0.05) in the TCGA‐KIRC dataset. (E) The 17 overlapping genes were enriched in the MAPK pathway based on the differentially expressed genes from RNA sequencing data or MYPT1‐correlated genes from TCGA‐KIRC dataset. ccRCC, renal clear cell carcinoma; GSEA, Gene Set Enrichment Analysis; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen‐activated protein kinase; MYPT1, myosin phosphatase target subunit 1.

    Journal: FEBS Open Bio

    Article Title: MYPT1 inhibits the metastasis of renal clear cell carcinoma via the MAPK8 /N‐cadherin pathway

    doi: 10.1002/2211-5463.13487

    Figure Lengend Snippet: RNA sequencing and bioinformatic analyses demonstrated that MYPT1 is involved in a MAPK‐related pathway in ccRCC. (A) The volcano plot shows genes differentially expressed between Caki1 cells with MYPT1 overexpression group and the negative control group ( P < 0.05). (B) KEGG analysis of the differentially expressed genes (¦log2FC¦ > 1, FDR‐adjusted P < 0.05) was performed in Caki1‐NC and Caki1‐MYPT1 cells. (C) GSEA revealed that the MAPK signalling pathway gene set was less enriched in Caki1‐MYPT1 cells (FDR < 25% and P < 0.05). (D) KEGG analysis of the MYPT1‐correlated genes ( P < 0.05) in the TCGA‐KIRC dataset. (E) The 17 overlapping genes were enriched in the MAPK pathway based on the differentially expressed genes from RNA sequencing data or MYPT1‐correlated genes from TCGA‐KIRC dataset. ccRCC, renal clear cell carcinoma; GSEA, Gene Set Enrichment Analysis; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen‐activated protein kinase; MYPT1, myosin phosphatase target subunit 1.

    Article Snippet: The human kidney cancer cell lines Caki1 and 769P were commercially provided by American Type Culture Collection (ATCC) and cultured as per ATCC's guidelines.

    Techniques: RNA Sequencing, Over Expression, Negative Control